Therapeutic Potential of Alstonia scholaris Latex in the Management of Inflammatory Diseases: An in vitro Approach

Pharmacognosy Research,2023,15,3,478-483.DOI:10.5530/pres.15.3.049Published:June 2023Type:Original Article Authors:Bapan Banik, and Malay Kumar Das Author(s) affiliations:Bapan Das* Department of Pharmaceutical Sciences, Drug Delivery Research Laboratory, Dibrugarh University, Dibrugarh, Assam, INDIA. Abstract:Background: The different parts Alstonia scholaris (AS) viz. leaf, bark root, latex are used traditionally to treat pain, swelling, stiffness, immune deficiency, malaria, ulcer, arthritis. traditional healers in Dhemaji district Assam prescribe raw AS for topical treatment inflammatory diseases. unique feature this study is that the has been evaluated scientifically first time its anti-inflammatory properties. Objectives: present investigation evaluates potential arthritis using vitro assays. Materials Methods: Anti-arthritic was assays bovine serum albumin (BSA) denaturation, egg human red blood cell (HRBC) membrane stabilization. Results: It observed standard diclofenac sodium showed good anti-arthritic potential. In BSA denaturation method, latex, 71.59% 85.23% inhibition proteinase enzyme at 250 μg/mL, respectively. maximum percentage protein 70.42% 81.32%, respectively, μg/mL. HRBC stabilization model, produced considerable a concentration–dependent manner. At μg/ mL hypotonic solution, 68.77% 72.12% stabilization, Conclusion: proved antiarthritic activity latex. may also be management other Keywords:Alstonia scholaris, Anti-arthritic, Anti-inflammatory, vitro., LatexView:PDF (226.19 KB)